Jury Elizabeth C, Flores-Borja Fabian, Kabouridis Panagiotis S
Centre for Rheumatology, Royal Free and University College Medical School, University College London, London W1P 4JF, United Kingdom.
Semin Cell Dev Biol. 2007 Oct;18(5):608-15. doi: 10.1016/j.semcdb.2007.08.002. Epub 2007 Aug 19.
Lipid rafts is a blanket term used to describe distinct areas in the plasma membrane rich in certain lipids and proteins and which are thought to perform diverse functions. A large number of studies report on lipid rafts having a key role in receptor signalling and activation of lymphocytes. In T cells, lipid raft involvement was demonstrated in the early steps during T cell receptor (TCR) stimulation. Interestingly, recent evidence has shown that signalling in these domains differs in T cells isolated from patients with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Here, we discuss these findings and explore the potential of lipid rafts as targets for the development of a new class of agents to downmodulate immune responses and for the treatment of autoimmune diseases.
脂筏是一个统称，用于描述质膜中富含某些脂质和蛋白质的不同区域，这些区域被认为具有多种功能。大量研究报道脂筏在受体信号传导和淋巴细胞激活中起关键作用。在T细胞中，脂筏参与了T细胞受体（TCR）刺激的早期步骤。有趣的是，最近的证据表明，在从自身免疫性疾病（如系统性红斑狼疮（SLE）和类风湿性关节炎（RA））患者中分离出的T细胞中，这些区域的信号传导有所不同。在此，我们讨论这些发现，并探讨脂筏作为开发新型药物以下调免疫反应和治疗自身免疫性疾病靶点的潜力。
