Schicknick Horst, Tischmeyer Wolfgang
Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany.
Neuropharmacology. 2006 May;50(6):671-6. doi: 10.1016/j.neuropharm.2005.11.013. Epub 2006 Jan 9.
The pharmacological basis of sensory cortex-dependent learning and associated cortical reorganizations is only partially understood. In the Mongolian gerbil, the auditory cortex is critical for discriminating the directions of modulation of linearly frequency-modulated tones (FMs). To examine the role of N-methyl-D-aspartate (NMDA)-type glutamate receptors in FM discrimination learning, selective antagonists were used. Compared to vehicle-treated controls, both systemic administration of MK-801 before but not after training, and infusion of D-AP-5 into the auditory cortex after training caused retention deficits detectable 24h later. The amnesic actions were reversible and in a close temporal relation to memory formation. Acquisition performance and performance of an established FM discrimination reaction were not affected. These findings suggest that NMDA receptor activation is required for long-term memory consolidation in auditory cortex-dependent learning.
感觉皮层依赖型学习及相关皮层重组的药理学基础仅得到部分理解。在蒙古沙鼠中，听觉皮层对于辨别线性调频音（FM）的调制方向至关重要。为了研究N-甲基-D-天冬氨酸（NMDA）型谷氨酸受体在FM辨别学习中的作用，使用了选择性拮抗剂。与给予赋形剂处理的对照组相比，训练前而非训练后全身给予MK-801，以及训练后向听觉皮层注入D-AP-5，均导致24小时后可检测到的记忆保持缺陷。遗忘作用是可逆的，且与记忆形成存在紧密的时间关系。习得表现和已建立的FM辨别反应的表现未受影响。这些发现表明，在听觉皮层依赖型学习中，长期记忆巩固需要NMDA受体激活。
