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输精管复通预测指标的多机构验证

Multi-institutional validation of vasectomy reversal predictor.

作者信息

Parekattil Sijo J, Kuang Wayne, Kolettis Peter N, Pasqualotto Fabio F, Teloken Patrick, Teloken Claudio, Nangia Ajay K, Daitch James A, Niederberger Craig, Thomas Anthony J

机构信息

Cleveland Clinic Foundation, Cleveland, Ohio, USA.

出版信息

J Urol. 2006 Jan;175(1):247-9. doi: 10.1016/S0022-5347(05)00027-3.

Abstract

PURPOSE

Some urologists who perform vasectomy reversals are not experienced with performing VE. A model to preoperatively identify patients who may require referral to an experienced VE surgeon was created (). We tested the model at multiple institutions.

MATERIALS AND METHODS

The model had previously been designed in 483 patients who underwent vasectomy reversal at 1 institution (100% sensitive and 59% specific for predicting the need for VE). It was based on time since vasectomy and patient age. We tested it prospectively in 33 patients and retrospectively in a total of 312 at 6 other institutions. The predictive accuracy of the model was compared to using a simple duration from vasectomy cutoff alone, as is used in clinical practice.

RESULTS

The model had 84% sensitivity and 58% specificity for detecting the need for VE in a total of 345 patients at 7 institutions. If using only a duration from vasectomy cutoff of 10 years to predict the need for VE, sensitivity was only 69%. At a cutoff of 4 years sensitivity was 99% but specificity was only 23%. Thus, the model performed better than any specific duration cutoff alone.

CONCLUSIONS

The predictive model provides 84% sensitivity for detecting patients who may require VE during vasectomy reversal across 7 institutions (58% specificity). The model more accurately predicts the need for VE than using a specific duration from vasectomy cutoff alone.

摘要

目的

一些实施输精管复通术的泌尿科医生对进行输精管端端吻合术(VE)缺乏经验。创建了一个术前识别可能需要转诊至经验丰富的VE外科医生的患者的模型()。我们在多个机构对该模型进行了测试。

材料与方法

该模型先前在一家机构接受输精管复通术的483例患者中设计(预测VE需求的敏感性为100%,特异性为59%)。它基于输精管结扎后的时间和患者年龄。我们对33例患者进行了前瞻性测试,并在其他6家机构对总共312例患者进行了回顾性测试。将该模型的预测准确性与临床实践中仅使用输精管结扎后的简单时间界限进行了比较。

结果

在7家机构的总共345例患者中,该模型检测VE需求的敏感性为84%,特异性为58%。如果仅使用输精管结扎后10年的时间界限来预测VE需求,敏感性仅为69%。在4年的界限时,敏感性为99%,但特异性仅为23%。因此,该模型的表现优于任何单独的特定时间界限。

结论

该预测模型在7家机构的输精管复通术中检测可能需要VE的患者时敏感性为84%(特异性为58%)。该模型比仅使用输精管结扎后的特定时间界限更准确地预测了VE需求。

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