未感染新生儿及疑似早发性细菌感染新生儿体内的脂多糖结合蛋白

Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection.

作者信息

Orlikowsky T W, Trüg C, Neunhoeffer F, Deperschmidt M, Eichner M, Poets C F

机构信息

Department of Neonatology, University Children's Hospital, Tübingen, Germany.

出版信息

J Perinatol. 2006 Feb;26(2):115-9. doi: 10.1038/sj.jp.7211422.

DOI:10.1038/sj.jp.7211422

PMID:16407966

Abstract

OBJECTIVES

To investigate postnatal lipopolysaccharide-binding protein (LBP) kinetics in term neonates and to test its diagnostic accuracy for early-onset bacterial infection (EOBI).

STUDY DESIGN

A total of 99 neonates with clinical and serological signs of EOBI comprised the study group; 198 neonates with risk factors, but without EOBI, served as controls. LBP, C-reactive protein (CRP) and interleukin-8 (IL-8) were determined.

RESULTS

LBP in the noninfected group increased until 24 h after birth (P < 0.05 vs 6 h). LBP and CRP correlated strongly in neonates with suspected EOBI (r = 0.63). Although LBP reached a higher sensitivity than CRP 6 and 12 h after clinical suspicion (45 (24-68) and 79% (54-94) vs 9 (0-24) and 39% (17-64); P < 0.05)), EOBI was most reliably detected by IL-8.

CONCLUSION

LBP kinetics were age-dependent. LBP was not sufficiently sensitive in the prediction of EOBI.

摘要

目的

研究足月儿出生后脂多糖结合蛋白（LBP）的动力学变化，并测试其对早发型细菌感染（EOBI）的诊断准确性。

研究设计

共有99例有EOBI临床和血清学体征的新生儿组成研究组；198例有危险因素但无EOBI的新生儿作为对照组。测定LBP、C反应蛋白（CRP）和白细胞介素-8（IL-8）。

结果

未感染组的LBP在出生后24小时内升高（与出生后6小时相比，P<0.05）。疑似EOBI的新生儿中，LBP与CRP密切相关（r = 0.63）。虽然在临床怀疑后6小时和12小时，LBP的敏感性高于CRP（分别为45%（24%-68%）和79%（54%-94%），而CRP分别为9%（0%-24%）和39%（17%-64%）；P<0.05），但IL-8对EOBI的检测最可靠。