Rodrigues Maria N, Queiroz Dulciene M M, Rodrigues Rodrigo T, Rocha Andreia M C, Braga Neto Manuel B, Braga Lucia L B C
Clinical Resaerch Unity-University Hospital Walter Cantideo, Department of Internal Medicine, Federal University of Ceará, Avenida José Bastos 3390, Porangabussu, Fortaleza, CE, Brazil.
Braz J Infect Dis. 2005 Oct;9(5):405-10. doi: 10.1590/s1413-86702005000500008. Epub 2006 Jan 6.
We investigated the prevalence and the risk factors for infection with Helicobacter pylori in a randomly-selected population of adults from a low-income community in Northeastern Brazil. Helicobacter pylori infection was determined by ELISA. Risk factors were assessed using a structured interview. Two hundred and four individuals were included in the study, including 49 males and 155 females, ranging from 18 to 80 years old. Overall, 165 of 204 participants (80%) were H. pylori positive, without significant gender differences (p= 0.49). The infection rate was of 84.7% in subjects 18 to 30 years of age, increasing to 92% in subjects 46-60 years old. Above 60 years old, the prevalence decreased slightly. As a whole, the prevalence of infection did not increase significantly (p=0.147) with age. There were no significant differences in the prevalence of H. pylori infection, when patients were classified by age, smoking habit, educational level, alcohol consumption, the number of persons per room, the number of children per household, the number of adults per household, cup-sharing, household pets, toilet location, number of persons per bed and medical history of antibiotic and raw vegetable ingestion. In conclusion, no risk factors associated with infection was found in these adults, suggesting that the infection, even in a poor population, may be acquired predominantly during childhood; the relatively high prevalence that we observed may be more due to a cohort effect than to acquisition of infection during adulthood.
我们对巴西东北部一个低收入社区的成年人群体进行了随机抽样，调查幽门螺杆菌感染的患病率及危险因素。通过酶联免疫吸附测定法（ELISA）确定幽门螺杆菌感染情况。使用结构化访谈评估危险因素。该研究共纳入204人，包括49名男性和155名女性，年龄在18至80岁之间。总体而言，204名参与者中有165人（80%）幽门螺杆菌呈阳性，无显著性别差异（p = 0.49）。18至30岁的受试者感染率为84.7%，46至60岁的受试者感染率增至92%。60岁以上，患病率略有下降。总体而言，感染患病率并未随年龄显著增加（p = 0.147）。根据年龄、吸烟习惯、教育程度、饮酒量、每间房居住人数、每户儿童数量、每户成年人数量、共用餐具、家庭宠物、厕所位置、每张床居住人数以及抗生素和生蔬菜摄入病史对患者进行分类时，幽门螺杆菌感染患病率无显著差异。总之，在这些成年人中未发现与感染相关的危险因素，这表明即使在贫困人口中，感染可能主要在儿童期获得；我们观察到的相对较高患病率可能更多是由于队列效应，而非成年期获得感染。
