Fialho André M N, Braga Andréa B C, Queiroz Dulciene M M, Rodrigues Maria N, Herbster Isabel D, Braga Lucia L B C
Clinical Research Unit, University Hospital Walter Cantideo/Department of Internal Medicine, Ceará Federal University, Brazil.
Ann Trop Paediatr. 2007 Mar;27(1):55-61. doi: 10.1179/146532807X170510.
An association between Helicobacter pylori infection and short stature in children has been described recently.
To describe differences in stature between H. pylori-infected and non-infected children in a low-income community in north-east Brazil.
H. pylori status was evaluated by 13C-urea-breath test; centile values for weight and height were calculated for each child.
The prevalence of H. pyloni was 55.8% (197/353) and increased with age. Of 197 H. pylori-positive children, 62% were below the 25th centile for height compared with 48% of H. pylori-negative children (75/156) [AOR (adjusted odds ratio) 1.61, 95% CI 1.04-2.49, p=0.03] after adjustment for variables with p < 0.25 in univariate analysis (gender, number of residents, of children per household and of persons per bed). These results were significant only when older children were included. Thus, in children aged 8-14 years, 80% (89/111) of H. pylori-positive were <25th centile for height compared with 63% (35/56) of H. pylori-negative children (p=0.01). Compared with children with a height >25th centile, the AOR for H. pylori infection increased from 2.42 in the crude analysis to 6.62 after adjustment (p=0.006).
H. pylori is associated with short stature in older children living in a poor urban community in Brazil.
最近有研究描述了幽门螺杆菌感染与儿童身材矮小之间的关联。
描述巴西东北部一个低收入社区中感染幽门螺杆菌和未感染幽门螺杆菌的儿童在身高方面的差异。
通过¹³C尿素呼气试验评估幽门螺杆菌感染状况；计算每个儿童体重和身高的百分位数。
幽门螺杆菌感染率为55.8%（197/353），且随年龄增长而升高。在197名幽门螺杆菌阳性儿童中，62%的儿童身高低于第25百分位数，相比之下，幽门螺杆菌阴性儿童（75/156）中这一比例为48%[调整后的优势比（AOR）为1.61，95%置信区间为1.04 - 2.49, p = 0.03]，这是在对单因素分析中p<0.25的变量（性别、居民数量、每户儿童数量和每张床的居住人数）进行调整之后得出的结果。这些结果仅在纳入年龄较大的儿童时具有统计学意义。因此，在8 - 14岁的儿童中，80%（89/111）的幽门螺杆菌阳性儿童身高低于第25百分位数，而幽门螺杆菌阴性儿童中这一比例为63%（35/56）（p = 0.01）。与身高高于第25百分位数的儿童相比，幽门螺杆菌感染的AOR从粗分析中的2.42增加到调整后的6.62（p = 0.006）。
在巴西一个贫困城市社区中，幽门螺杆菌感染与年龄较大儿童的身材矮小有关。
