Schöbitz B, Voorhuis D A, De Kloet E R
Max-Planck-Institute for Psychiatry, Clinical Institute, Munich, FRG.
Neurosci Lett. 1992 Mar 2;136(2):189-92. doi: 10.1016/0304-3940(92)90046-a.
The cytokine interleukin 6 (IL6) has several effects on the central nervous system in addition to the well established regulation of the acute phase inflammatory response. Therefore, the distribution of IL6- and IL6 receptor mRNA in the rat brain has been investigated by in situ hybridization using [35S]-labeled oligonucleotides. The messages of both genes were found in the CA1-CA4 regions as well as in the dentate gyrus of the hippocampus, in the habenulae, the dorsomedial and the ventromedial hypothalamus, in the internal capsule, the optic tract and in the piriform cortex. These data indicate both neuronal and glial localization of IL6 and IL6 receptor and their involvement in an autocrine or paracrine action of the cytokine in centrally regulated functions including neuroendocrine control.
细胞因子白细胞介素6（IL6）除了对急性期炎症反应具有公认的调节作用外，还对中枢神经系统有多种影响。因此，已使用[35S]标记的寡核苷酸通过原位杂交研究了IL6和IL6受体mRNA在大鼠脑中的分布。在CA1-CA4区域以及海马齿状回、缰核、背内侧和腹内侧下丘脑、内囊、视束和梨状皮质中均发现了这两种基因的信息。这些数据表明IL6和IL6受体在神经元和胶质细胞中的定位，以及它们在包括神经内分泌控制在内的中枢调节功能中参与细胞因子的自分泌或旁分泌作用。
