Hasan Kadhum Al-Huchaimi S, Hameed Neamah Al-Kefaei G, Ahmed Alameedy B
Department of Medical Laboratory Techniques, Imam Ja'afar Al-Sadiq University, Al-Najaf, Iraq.
Arch Razi Inst. 2022 Feb 28;77(1):213-220. doi: 10.22092/ARI.2021.356478.1850. eCollection 2022 Feb.
Parkinson's disease (PD) is a psychiatric neurological infection of the focal sensory system and is accepted as a multifactorial disease. Chronic Toxoplasmosis is sometimes associated with the proliferation of bradyzoites in the nervous system. The measurement of interleukin-5 (IL-5) as an inflammatory mediator in patients with PD and Toxoplasmosis infection may be helpful in determining the correlation between these diseases. In the present study, 80 examples were collected, including 35 patients diagnosed with idiopathic PD and 45 samples from healthy people from Najaf, Babylon, and Baghdad provinces, Iraq. After measuring the immunoglobulin G (IgG) antibody of , the level of IL-5 was evaluated in different groups. Serological examination showed that the IgG antibody of Toxoplasmosis increased (<0.05) in people with PD (65.71%). Serum levels of IL-5 significantly decreased in people with PD. It is noteworthy that comparing serum levels of IL-5 between two groups of people with and without chronic Toxoplasmosis revealed that there was a significant decrease (<0.05) in a concentration of serum IL-5 in individuals with chronic Toxoplasmosis. The current study confirmed the conceivable association between and PD, and further research is recommended to explain the association between PD and Toxoplasmosis.
帕金森病（PD）是一种中枢神经系统的精神性神经感染性疾病，被认为是一种多因素疾病。慢性弓形虫病有时与缓殖子在神经系统中的增殖有关。测量白细胞介素-5（IL-5）作为PD和弓形虫感染患者的炎症介质，可能有助于确定这些疾病之间的相关性。在本研究中，收集了80份样本，包括35名被诊断为特发性PD的患者和45份来自伊拉克纳杰夫、巴比伦和巴格达省健康人的样本。在测量了[此处原文缺失具体测量对象]的免疫球蛋白G（IgG）抗体后，对不同组的IL-5水平进行了评估。血清学检查显示，PD患者中弓形虫病的IgG抗体增加（<0.05）（65.71%）。PD患者的血清IL-5水平显著降低。值得注意的是，比较有和没有慢性弓形虫病的两组人群的血清IL-5水平发现，慢性弓形虫病患者的血清IL-5浓度显著降低（<0.05）。本研究证实了[此处原文缺失具体关联对象]与PD之间可能存在的关联，建议进一步研究以解释PD与弓形虫病之间的关联。
