Abdulovic Amy, Kim Nayun, Jinks-Robertson Sue
Biochemistry, Cell and Developmental Biology Program of the Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.
DNA Repair (Amst). 2006 Apr 8;5(4):409-21. doi: 10.1016/j.dnarep.2005.11.006. Epub 2006 Jan 10.
Mutagenesis is a prerequisite for evolution and also is an important contributor to human diseases. Most mutations in actively dividing cells originate during DNA replication as errors introduced when copying an undamaged DNA template or during the bypass of DNA lesions. In addition, mutations can be introduced during the repair of DNA double-strand breaks by either homologous recombination or non-homologous end-joining pathways. Finally, although generally considered to be a very high-fidelity process, the excision repair of DNA damage may be an important contributor to mutagenesis in non-dividing cells. In this review, we will discuss the well-known contributions of DNA replication to mutagenesis in Saccharomyces cerevisiae, as well as the less-appreciated contributions of recombination and repair to mutagenesis in this organism.
诱变是进化的先决条件，也是人类疾病的一个重要促成因素。活跃分裂细胞中的大多数突变起源于DNA复制过程，即复制未受损DNA模板时引入的错误，或DNA损伤旁路过程中引入的错误。此外，在通过同源重组或非同源末端连接途径修复DNA双链断裂的过程中也会引入突变。最后，尽管DNA损伤的切除修复通常被认为是一个非常高保真的过程，但它可能是非分裂细胞中诱变的一个重要促成因素。在这篇综述中，我们将讨论DNA复制对酿酒酵母诱变的众所周知的贡献，以及重组和修复对该生物体诱变的鲜为人知的贡献。
