人脑中诱导型热休克70蛋白水平升高。

Elevated levels of inducible heat shock 70 proteins in human brain.

作者信息

Pardue S, Wang S, Miller M M, Morrison-Bogorad M

机构信息

Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, United States.

出版信息

Neurobiol Aging. 2007 Feb;28(2):314-24. doi: 10.1016/j.neurobiolaging.2005.12.001. Epub 2006 Jan 18.

DOI:10.1016/j.neurobiolaging.2005.12.001

PMID:16413087

Abstract

Differential expression of heat shock genes can modulate protein folding and stress-related cell death. There have been no comparisons of their levels of expression in animals and humans. Levels of expression of heat shock 70 genes in human brain were compared to levels in non-stressed and heat-stressed brain of rat. Levels of hsp70 proteins in human brain were 43-fold higher than in non-stressed rat brain and 14-fold higher than highest induced levels in brains of heat-shocked rats. Levels of constitutively synthesized hsc70 proteins were approximately 1.5-fold higher in human than in rat. Higher levels of hsp70 proteins in human brain may serve to protect brain cells against stress-related death or dysfunction throughout the lifespan.

摘要

热休克基因的差异表达可调节蛋白质折叠及与应激相关的细胞死亡。目前尚未对其在动物和人类中的表达水平进行比较。将人类大脑中热休克70基因的表达水平与非应激和热应激大鼠大脑中的水平进行了比较。人类大脑中hsp70蛋白的水平比非应激大鼠大脑高43倍，比热休克大鼠大脑中最高诱导水平高14倍。组成型合成的hsc70蛋白水平在人类中比在大鼠中约高1.5倍。人类大脑中较高水平的hsp70蛋白可能有助于在整个生命周期中保护脑细胞免受与应激相关的死亡或功能障碍。