Ho Shu Fen, Mathew M R K, Wykes W, Lavy T, Marshall T
Department of Ophthalmology, Southern General Hospital, Glasgow, United Kingdom.
J AAPOS. 2005 Dec;9(6):584-8. doi: 10.1016/j.jaapos.2005.07.007.
We sought to find out whether birth weight of less than 1251 g or gestational age less than 30 weeks could provide a safe and efficient screening criteria of detecting treatable retinopathy of prematurity (ROP).
Infants either with a birth weight less than 1500 g or gestational age less than 32 weeks were screened for ROP during an 8-year period.
In our study, the incidence of ROP was 36 of 187 (19.3%) infants. Although there was a slight increase in the number of infants screened over the years, the incidence of ROP of any stage remained stable. The maximum stage of ROP reached was stage 1 in 10 of 187 (5.3%), stage 2 in 8 of 187 (4.3%), and stage 3 in 18 of 187 (9.6%) infants. Among those with stage 3 disease, threshold ROP was present in 16 of 18 (88.9%). All infants with threshold ROP had a BW less than 1100 g and gestational age less than or equal to 28 weeks. Significantly fewer babies (105/187, or 56%) would have been examined had inclusion criteria of a birth weight of less than 1251 g and gestational age less than 30 weeks been applied. In addition, 31% (134/437) of screening examinations could have been avoided.
Our study suggests that a birth weight of less than 1251 g and gestational age less than 30 weeks can be safely and efficiently used to screen infants without missing a diagnosis of sight-threatening ROP in our catchment population.
我们试图查明出生体重低于1251克或胎龄小于30周是否能提供一个安全有效的筛查标准，用于检测可治疗的早产儿视网膜病变（ROP）。
在8年期间，对出生体重低于1500克或胎龄小于32周的婴儿进行ROP筛查。
在我们的研究中，187名婴儿中有36名（19.3%）发生ROP。尽管多年来筛查的婴儿数量略有增加，但任何阶段的ROP发病率保持稳定。ROP达到的最大阶段为：187名婴儿中有10名（5.3%）为1期，187名婴儿中有8名（4.3%）为2期，187名婴儿中有18名（9.6%）为3期。在患有3期疾病的婴儿中，18名中有16名（88.9%）存在阈值ROP。所有患有阈值ROP的婴儿出生体重均低于ll00克，胎龄小于或等于28周。如果采用出生体重低于1251克和胎龄小于30周的纳入标准，接受检查的婴儿数量将显著减少（105/187，即56%）。此外，31%（134/437）的筛查检查本可避免。
我们的研究表明，出生体重低于1251克和胎龄小于30周可安全有效地用于筛查婴儿，而不会漏诊我们所研究人群中具有视力威胁的ROP。
