Bourdel-Marchasson I, Berrut G
Département de Gériatrie, Hôpital Xavier-Arnozan, CHU de Bordeaux, F-33604 Pessac Cedex, France.
Diabetes Metab. 2005 Dec;31 Spec No 2:5S13-5S19. doi: 10.1016/s1262-3636(05)73647-8.
Successful aging and frailty are emerging constructs becoming necessary to define prevention and treatment goals in elderly subjects. Frailty corresponds to the stages between full autonomy or successful aging and irreversible functional dependency or pathological aging. However its definition is imprecise and potential clinical criteria are numerous and interrelated. Diabetes decreases the likelihood for successful aging and particularly increases the risk for functional dependency. One major end-point in the care of elderly diabetic subjects is to investigate the impact of blood glucose control on progression of disability. Geriatric intervention based on comprehensive geriatric assessment (CGA) in the frail elderly population has been shown effective to prevent the loss of autonomy and to improve quality of life, but seems ineffective on mortality. It is now recommended to screen elderly diabetic patients for frailty criteria. The effect of combined individualized diabetes care and CGA on the aging profile should be investigated.
成功老龄化和衰弱是正在兴起的概念,对于界定老年人群的预防和治疗目标变得十分必要。衰弱对应于完全自主或成功老龄化与不可逆功能依赖或病理性衰老之间的阶段。然而,其定义并不精确,潜在的临床标准众多且相互关联。糖尿病会降低成功老龄化的可能性,尤其会增加功能依赖的风险。老年糖尿病患者护理的一个主要终点是研究血糖控制对残疾进展的影响。在衰弱老年人群中基于综合老年评估(CGA)的老年干预已被证明可有效预防自主性丧失并改善生活质量,但对死亡率似乎无效。现在建议对老年糖尿病患者进行衰弱标准筛查。应研究个体化糖尿病护理与CGA相结合对老龄化状况的影响。