I Bourdel-Marchasson, CNRS/Université de Bordeaux, UMR 5536 Résonance Magnétique des systèmes Biologiques, Bordeaux, France,
J Nutr Health Aging. 2019;23(7):637-640. doi: 10.1007/s12603-019-1229-3.
Muscle alterations, mainly functional alterations are frequently observed in older people with type 2 diabetes (T2DM). Sarcopenia may be one mechanism of transition to frailty in these people. Thus, we aim to explore the characteristics of muscle and its association with cerebral grey matter volumes within this group.
Single center study nested within the international MID-Frail (a randomized clinical trial to evaluate the effectiveness of a multi-modal intervention in older people with T2DM on frailty and quality of life) trial participants underwent both brain and muscle T1 MRI, nutritional and functional assessments. Muscle areas were measured in rectus femoris (RF). Relationships between MRI grey matter volumes and muscle areas or function tests were described using positive and negative regressions.
Twenty-six subjects (7 female, mean age 78.2 y, SD 5.0), 6 frail and 20 pre-frail were explored in this sub-study. Frail subjects had lower Mini Nutritional Assessment (MNA), Short Physical Performance Battery (SPPB), hip flexor strength than pre-frail ones but similar BMI and balance. Total SPPB was positively related with hip flexor strength and maximal RF area. Balance SPPB sub-score was unrelated to strength or RF area. MNA score was correlated with hip flexor strength and to global grey matter but not to SPPB. Hip flexor strength was correlated with grey matter areas involved in motor control. Walking time was negatively and rising chair sub-score was positively associated with grey matter volumes of motor areas.
Sarcopenia features were more frequent in frail than prefrail subjects and were associated with decrease in grey matter volumes involved in motor control.
2 型糖尿病（T2DM）老年人常出现肌肉改变，主要为功能性改变。肌少症可能是这些人向虚弱状态转变的机制之一。因此，我们旨在探讨该人群肌肉特征及其与大脑灰质体积的关系。
这项单中心研究嵌套在国际 MID-Frail 研究中（一项评估多模式干预对 T2DM 老年患者虚弱和生活质量影响的随机临床试验），参与者接受了大脑和肌肉 T1 MRI、营养和功能评估。股直肌（RF）的肌肉面积进行了测量。使用正回归和负回归描述 MRI 灰质体积与肌肉面积或功能测试之间的关系。
本亚研究共纳入 26 名受试者（7 名女性，平均年龄 78.2 岁，标准差 5.0），其中 6 名虚弱，20 名虚弱前期。虚弱组的 Mini Nutritional Assessment（MNA）、Short Physical Performance Battery（SPPB）、髋关节屈肌力量低于虚弱前期组，但 BMI 和平衡相似。总 SPPB 与髋关节屈肌力量和最大 RF 面积呈正相关。平衡 SPPB 子评分与力量或 RF 面积无关。MNA 评分与髋关节屈肌力量和全脑灰质相关，但与 SPPB 无关。髋关节屈肌力量与参与运动控制的灰质区域相关。行走时间呈负相关，起坐子评分与运动区灰质体积呈正相关。
与虚弱前期组相比，虚弱组的肌少症特征更为常见，且与参与运动控制的灰质体积减少相关。
