Hauck E W, Diemer T, Weidner W
Klinik und Poliklinik für Urologie und Kinderurologie der Justus-Liebig-Universität Giessen, Universitätsklinikum Giessen und Marburg.
Urologe A. 2006 Feb;45(2):W243-57. doi: 10.1007/s00120-005-0988-0.
Peyronie's disease is characterized by the formation of a plaque of the tunica albuginea that leads to a mainly dorsally directed penile curvature and penile shortening due to scarification. The exact ethiopathology remains unclear. The natural history of the disease is variable, ranging from spontaneous remissions to chronic, and including severe penile curvature. Therapy should be conservative in the early, painful, progressive phase. No conservative medical or semi-invasive treatment modality, such as extracorporeal shock wave therapy or radiation therapy, is currently available for curing all of the symptoms of this disorder in all patients. All studies with a controlled design showed poor therapeutic outcomes that are frequently identical to the natural course. Surgical therapy should only be performed in the stable stage of the disease. This means that Peyronie's disease should have been present for at least 12 months, and the patient should not have suffered from pain or the progression of symptoms for at least 6 months. The surgical treatment modalities comprise plication procedures (Essed-Schroeder, Nesbit), plaque-incisions with grafting, and the insertion of penile implants with simultaneous correction of the curvature by "penile cracking" or incisions of the plaque.
佩罗尼氏病的特征是白膜形成斑块，导致阴茎主要向背侧弯曲，并因瘢痕形成而阴茎缩短。确切的病因病理尚不清楚。该病的自然病程多变，从自发缓解到慢性病程，包括严重的阴茎弯曲。在疾病早期、疼痛且进展期，治疗应采取保守方法。目前尚无保守的药物或半侵入性治疗方式，如体外冲击波疗法或放射疗法，能治愈所有患者的该疾病所有症状。所有对照设计的研究均显示治疗效果不佳，且常常与自然病程相同。手术治疗仅应在疾病的稳定期进行。这意味着佩罗尼氏病应已存在至少12个月，且患者至少6个月未出现疼痛或症状进展。手术治疗方式包括折叠手术（埃塞德 - 施罗德、内斯比特）、斑块切开加移植，以及插入阴茎假体并通过“阴茎折断”或斑块切开同时矫正弯曲。
