Wilson Robert, Jackson Jeffrey, Rassekh Christopher
Div. of Otolaryngology, University of Kentucky, Lexington, USA.
W V Med J. 2005 Sep-Oct;101(5):217-9.
The goal of this study was to review the patterns of relapse and outcome for patients with squamous cell carcinoma of the lip treated at West Virginia University Hospitals, and to assess the tumor factors that may influence the prognosis of patients. A total of 52 patients were identified in a retrospective review of all lip cancer patients referred to West Virginia University Hospitals between 1980 and 2000. Relevant data was extracted from the medical records of each patient, as well as information from the Cancer Registry. Most patients were men (86%) with T1N0 cancers (52%) of the lower lip. Less than 10% had nodal disease at diagnosis. Following treatment, 31% of patients relapsed, 7 at the primary site and 9 at regional lymph nodes. The relapse rate was 15% for T1 lesions, whereas it increased to 44% for T2 lesions. The overall crude 5-year survival rate was 69%. These findings highlight an increased relapse rate and mortality for a subgroup of patients diagnosed with a more aggressive form of lip cancer. Treatment and follow up of these patients should accordingly be more aggressive.
本研究的目的是回顾在西弗吉尼亚大学医院接受治疗的唇鳞状细胞癌患者的复发模式和预后情况，并评估可能影响患者预后的肿瘤因素。在对1980年至2000年间转诊至西弗吉尼亚大学医院的所有唇癌患者进行的回顾性研究中，共确定了52例患者。从每位患者的病历以及癌症登记处提取了相关数据。大多数患者为男性（86%），下唇患有T1N0癌症（52%）。诊断时不到10%的患者有淋巴结疾病。治疗后，31%的患者复发，7例在原发部位，9例在区域淋巴结。T1病变的复发率为15%，而T2病变的复发率则升至44%。总体粗5年生存率为69%。这些发现突出了诊断为侵袭性更强的唇癌亚组患者的复发率和死亡率增加。因此，对这些患者的治疗和随访应更积极。
