Bourne W M, Brubaker R F
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905.
Am J Ophthalmol. 1992 Aug 15;114(2):171-81. doi: 10.1016/s0002-9394(14)73981-9.
We observed three women with partial corneal involvement in the iridocorneal endothelial syndrome for more than ten years. During this time, the peripheral anterior synechiae progressed in all three, with one patient developing glaucoma. In two patients, the abnormal endothelial cells spread to cover the entire posterior corneal surface; in the third, they disappeared almost entirely. The endothelial permeability to fluorescein remained abnormally low only in the two eyes with diffusely abnormal endothelium, and increased to normal in the third eye as the abnormal endothelium disappeared. The permeability in the third eye had been abnormally low only in the superior half of the cornea, where the abnormal endothelium was located. As the abnormal endothelium regressed, it was replaced by normal endothelium with a normal cell density similar to that of the unaffected fellow eye. Thus, for more than ten years, the partial endothelial involvement associated with the iridocorneal endothelial syndrome progressed substantially in two patients and regressed dramatically in a third.
我们观察了三名患有虹膜角膜内皮综合征且角膜部分受累的女性超过十年。在此期间，三名患者的周边前粘连均有进展，其中一名患者发展为青光眼。两名患者中，异常内皮细胞扩散至覆盖整个角膜后表面；第三名患者的异常内皮细胞几乎完全消失。仅在两只内皮广泛异常的眼中，内皮对荧光素的通透性仍异常低，而在第三只眼中，随着异常内皮消失，通透性恢复正常。第三只眼中，仅在角膜上半部分（即异常内皮所在部位）通透性曾异常低。随着异常内皮消退，其被正常内皮取代，细胞密度与未受影响的对侧眼相似。因此，在超过十年的时间里，两名患有虹膜角膜内皮综合征且伴有部分内皮受累的患者病情大幅进展，而第三名患者病情则显著消退。
