Alladi Suvarna, Arnold Robert, Mitchell Joanna, Nestor Peter J, Hodges John R
Department of Clinical Neurosciences, University of Cambridge, UK.
Psychol Med. 2006 Apr;36(4):507-15. doi: 10.1017/S0033291705006744. Epub 2006 Jan 23.
We explored the applicability of recently proposed research criteria for mild cognitive impairment (MCI) in a memory clinic and changes in case definition related to which memory tests are used and the status of general cognitive function in MCI.
A total of 166 consecutive GP referrals to the Cambridge Memory Clinic underwent comprehensive neuropsychological and psychiatric evaluation.
Of 166 cases, 42 were excluded (significant depression 8, established dementia 29 and other disorders 5). Of 124 non-demented, non-depressed patients, 72 fulfilled Petersen's criteria for amnestic MCI based upon verbal memory performance [the Rey Auditory Verbal Learning Test (RAVLT)] and 90 met criteria if performance on verbal and/or non-verbal memory tests [the Rey figure recall or the Paired Associates Learning test (PAL)] was considered. Of the 90 broadly defined MCI cases, only 25 had pure amnesia: other subtle semantic and/or attention deficits were typically present. A further 12 were classed as non-amnestic MCI and 22 as 'worried well'.
Definition of MCI varies considerably dependent upon the tests used for case definition. The majority have other cognitive deficits despite normal performance on the Mini-mental State Examination (MMSE) and intact activities of daily living (ADL) and fit within multi-domain MCI. Pure amnesic MCI is rare.
我们探讨了最近提出的轻度认知障碍（MCI）研究标准在记忆门诊中的适用性，以及与所使用的记忆测试和MCI患者一般认知功能状态相关的病例定义变化。
共有166名连续被全科医生转诊至剑桥记忆门诊的患者接受了全面的神经心理学和精神科评估。
166例患者中，42例被排除（严重抑郁症8例，已确诊痴呆29例，其他疾病5例）。在124例非痴呆、非抑郁患者中，72例根据言语记忆表现[雷伊听觉词语学习测验（RAVLT）]符合彼得森遗忘型MCI标准，若考虑言语和/或非言语记忆测试[雷伊图形回忆或配对联想学习测验（PAL）]的表现，则有90例符合标准。在90例广义定义的MCI病例中，只有25例有单纯遗忘：通常还存在其他细微的语义和/或注意力缺陷。另有12例被归类为非遗忘型MCI，22例为“健康焦虑者”。
MCI的定义因用于病例定义的测试不同而有很大差异。尽管简易精神状态检查表（MMSE）表现正常且日常生活活动（ADL）完好，但大多数患者存在其他认知缺陷，属于多领域MCI。单纯遗忘型MCI很少见。
