Lonie Jane A, Herrmann Lucie L, Donaghey Claire L, Ebmeier Klaus P
University of Edinburgh Division of Psychiatry, Royal Edinburgh Hospital, Edinburgh, UK.
Br J Psychiatry. 2008 Jan;192(1):59-64. doi: 10.1192/bjp.bp.107.035642.
There is current interest in exploring the different subtypes of mild cognitive impairment (MCI), in terms of both their epidemiology and their cognitive profile.
To examine the frequency of MCI subtypes presenting to a memory clinic and to document detailed neuropsychological profiles of patients with the amnestic subtype.
Consecutive tertiary referrals (n=187) were psychiatrically evaluated; 45 patients met criteria for amnestic mild cognitive impairment (aMCI). A subgroup of 33 patients with aMCI as well as 21 healthy controls took part in a thorough neuropsychological examination.
Of the patients who were examined in greater neuropsychological detail, ten had pure aMCI (none with visual memory impairment only). Fifteen met criteria for non-amnestic MCI. Fifteen had normal neuropsychological profiles. Using more than one test increased sensitivity to detect episodic memory impairment.
Amnestic MCI is an important diagnosis in secondary and tertiary memory clinics. There is scope to improve the efficacy and sensitivity of the clinical assessment of this impairment.
目前人们对探索轻度认知障碍（MCI）的不同亚型在流行病学和认知特征方面的情况很感兴趣。
研究记忆门诊中MCI亚型的出现频率，并记录遗忘型亚型患者的详细神经心理学特征。
对连续的三级转诊患者（n = 187）进行精神科评估；45名患者符合遗忘型轻度认知障碍（aMCI）的标准。33名aMCI患者以及21名健康对照组成的亚组参与了全面的神经心理学检查。
在接受更详细神经心理学检查的患者中，10名患有单纯aMCI（均无仅视觉记忆受损情况）。15名符合非遗忘型MCI标准。15名神经心理学特征正常。使用多种测试可提高检测情景记忆障碍的敏感性。
遗忘型MCI在二级和三级记忆门诊中是重要诊断。改善这种障碍临床评估的有效性和敏感性仍有空间。
