Xie Youzhuan, Chopin Daniel, Morin Christian, Hardouin Pierre, Zhu Zhenan, Tang Jian, Lu Jianxi
Department of Orthopaedic Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 200011 Shanghai, China.
Biomaterials. 2006 May;27(13):2761-7. doi: 10.1016/j.biomaterials.2005.12.011. Epub 2006 Jan 19.
The histological reports on porous biphasic calcium phosphate ceramic (PBC) in human spine are limited. The osteogenesis and biodegradation of PBC are insufficiently known in human. In present study, the undecalcified histological study was carried out on 20 samples retrieved from posterior spinal fusion in order to reveal the osteogenesis and biodegradation of the PBC in human spine. The quantitative study was performed in 14 samples with sufficient size. Newly formed bone was found in all the samples. More new bone was formed in those samples closely in contact with autogenous bone. The PBC degradation particles were present both in the macrophages and around the tissue. However, those phenomena were highly variable among the samples. New bone formation increased with time and decreased with age. The PBC degradation decreased with age, but it did not differ greatly with time. New bone formation was higher and the residual material was lower in the fusion group than that in non-fusion group. The PBC is a kind of osteoconductive material and do not transform into new bone after a relatively long time. The PBC should be well mixed with the autogenous bone in order to achieve high new bone colonization. The PBC degradation particles and related active phagocytotic activity have been noted.
关于多孔双相磷酸钙陶瓷（PBC）在人体脊柱中的组织学报告有限。PBC在人体中的成骨作用和生物降解情况尚不完全清楚。在本研究中，对从后路脊柱融合术中获取的20个样本进行了不脱钙组织学研究，以揭示PBC在人体脊柱中的成骨作用和生物降解情况。对14个尺寸足够的样本进行了定量研究。在所有样本中均发现了新形成的骨组织。在那些与自体骨紧密接触的样本中形成了更多的新骨。PBC降解颗粒存在于巨噬细胞内和组织周围。然而，这些现象在样本之间差异很大。新骨形成随时间增加而随年龄减少。PBC降解随年龄减少，但随时间变化不大。融合组的新骨形成较高，残留物质较少，而非融合组则相反。PBC是一种骨传导材料，在较长时间后不会转化为新骨。为了实现高的新骨定植，PBC应与自体骨充分混合。已注意到PBC降解颗粒及相关的活跃吞噬活性。
