Lehmann Alan R
Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK.
DNA Repair (Amst). 2006 Mar 7;5(3):404-7. doi: 10.1016/j.dnarep.2005.12.005. Epub 2006 Jan 19.
Translesion synthesis is an important mechanism by which cells replicate past DNA damage. The sliding clamp DNA polymerase processivity factors play a central role in this process. The clamps are dimeric in bacteria and trimeric in eukaryotes and archaea, raising the question of whether more than one polymerase can interact with the clamp simultaneously. Recently published data suggest that this is indeed the case.
跨损伤合成是细胞绕过DNA损伤进行复制的重要机制。滑动夹DNA聚合酶持续合成因子在这一过程中发挥核心作用。夹子在细菌中是二聚体，在真核生物和古细菌中是三聚体，这就提出了一个问题，即是否有不止一种聚合酶能同时与夹子相互作用。最近发表的数据表明情况确实如此。
