Barsky Daniel, Venclovas Ceslovas
Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Ave, L-448, Livermore, California 94550, USA.
Curr Biol. 2005 Dec 20;15(24):R989-92. doi: 10.1016/j.cub.2005.11.047.
Two recent papers illuminate a key step in DNA sliding clamp loading: one reveals the structure of the PCNA clamp wrapped around DNA--still open from being loaded--while the other finds that the clamp may assist this process by forming a right-handed helix upon opening.
最近的两篇论文阐明了DNA滑动夹加载过程中的一个关键步骤：一篇揭示了围绕DNA的增殖细胞核抗原（PCNA）夹的结构——在加载后仍处于开放状态——而另一篇则发现该夹在打开时可能通过形成右手螺旋来辅助这一过程。
