Vivas E, Skovran E, Downs D M
Department of Bacteriology, University of Wisconsin-Madison, 420 Henry Mall, Madison, WI 53706-1502, USA.
J Bacteriol. 2006 Feb;188(3):1175-9. doi: 10.1128/JB.188.3.1175-1179.2006.
In Salmonella enterica, the isc operon contains genes necessary for the synthesis of Fe-S clusters and strains lacking this operon have severe defects in a variety of cellular processes. Other cellular loci that impact Fe-S cluster synthesis to a lesser extent have been described. The cyaY locus encodes a frataxin homolog, and it is shown here that lesions in this locus affect Fe-S cluster metabolism. When present in combination with other lesions, mutations in cyaY can result in a strain with more severe defects than those lacking the isc locus.
在肠炎沙门氏菌中，isc操纵子包含铁硫簇合成所必需的基因，缺乏该操纵子的菌株在多种细胞过程中存在严重缺陷。已经描述了其他对铁硫簇合成影响较小的细胞位点。cyaY位点编码一种frataxin同源物，本文表明该位点的损伤会影响铁硫簇代谢。当与其他损伤同时存在时，cyaY中的突变会导致产生一种缺陷比缺乏isc位点的菌株更严重的菌株。
