铁硫簇的形成是如何被调控的？
How Is Fe-S Cluster Formation Regulated?
作者信息
Mettert Erin L, Kiley Patricia J
机构信息
Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, email:
出版信息
Annu Rev Microbiol. 2015;69:505-26. doi: 10.1146/annurev-micro-091014-104457.
Abstract
Iron-sulfur (Fe-S) clusters are fundamental to numerous biological processes in most organisms, but these protein cofactors can be prone to damage by various oxidants (e.g., O2, reactive oxygen species, and reactive nitrogen species) and toxic levels of certain metals (e.g., cobalt and copper). Furthermore, their synthesis can also be directly influenced by the level of available iron in the environment. Consequently, the cellular need for Fe-S cluster biogenesis varies with fluctuating growth conditions. To accommodate changes in Fe-S demand, microorganisms employ diverse regulatory strategies to tailor Fe-S cluster biogenesis according to their surroundings. Here, we review the mechanisms that regulate Fe-S cluster formation in bacteria, primarily focusing on control of the Isc and Suf Fe-S cluster biogenesis systems in the model bacterium Escherichia coli.
摘要
铁硫（Fe-S）簇对于大多数生物体中的众多生物学过程至关重要，但这些蛋白质辅因子容易受到各种氧化剂（如O2、活性氧和活性氮）以及某些金属（如钴和铜）的毒性水平的损害。此外，它们的合成也会直接受到环境中可用铁水平的影响。因此，细胞对Fe-S簇生物合成的需求会随着生长条件的波动而变化。为了适应Fe-S需求的变化，微生物采用多种调节策略，根据周围环境来调整Fe-S簇的生物合成。在这里，我们综述了细菌中调节Fe-S簇形成的机制，主要聚焦于模式细菌大肠杆菌中Isc和Suf Fe-S簇生物合成系统的调控。
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