mxiE中的转录滑动控制下游mxiD基因的转录和翻译，mxiD基因编码福氏志贺菌III型分泌装置的一个组件。
Transcriptional slippage in mxiE controls transcription and translation of the downstream mxiD gene, which encodes a component of the Shigella flexneri type III secretion apparatus.
作者信息
Penno Christophe, Parsot Claude
机构信息
Unité de Pathogénie Microbienne Moléculaire, INSERM U389, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris Cedex 15, France.
出版信息
J Bacteriol. 2006 Feb;188(3):1196-8. doi: 10.1128/JB.188.3.1196-1198.2006.
Abstract
The Shigella flexneri transcription activator MxiE is produced by transcriptional slippage from two overlapping open reading frames. By using plasmids encoding a mxiD-lacZ translational fusion, we showed that transcriptional slippage in mxiE influences both transcription and translation of the downstream mxiD gene encoding an essential component of the type III secretion apparatus.
摘要
福氏志贺菌转录激活因子MxiE由两个重叠的开放阅读框通过转录滑动产生。通过使用编码mxiD-lacZ翻译融合体的质粒，我们发现mxiE中的转录滑动会影响下游mxiD基因的转录和翻译，该基因编码III型分泌装置的一个必需组分。
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