Vetrivel Kulandaivelu S, Thinakaran Gopal
Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA.
Neurology. 2006 Jan 24;66(2 Suppl 1):S69-73. doi: 10.1212/01.wnl.0000192107.17175.39.
Trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations in the past two decades, since the identification of Abeta as the principal component of brain senile plaques and the cloning of APP cDNA. Tremendous progress has been made in the recent past toward the characterization of beta- and gamma-secretases. Here, we review the salient features of Alzheimer disease amyloidogenesis, and discuss the current knowledge on APP trafficking and amyloidogenic processing of APP in intracellular membrane compartments and microdomains.
自从β淀粉样蛋白被确定为脑老年斑的主要成分以及淀粉样前体蛋白（APP）的cDNA被克隆以来，在过去二十年中，APP的转运和蛋白水解加工一直是众多研究的焦点。最近，在β-和γ-分泌酶的特性研究方面取得了巨大进展。在这里，我们回顾了阿尔茨海默病淀粉样蛋白生成的显著特征，并讨论了目前关于APP在细胞内膜隔室和微区中的转运及淀粉样蛋白生成加工的知识。
