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人类肠道黏膜肥大细胞:超微结构观察及体内肥大细胞与神经关联的解剖学变异

Human gut mucosal mast cells: ultrastructural observations and anatomic variation in mast cell-nerve associations in vivo.

作者信息

Dvorak A M, McLeod R S, Onderdonk A B, Monahan-Earley R A, Cullen J B, Antonioli D A, Morgan E, Blair J E, Estrella P, Cisneros R L

机构信息

Department of Pathology, Beth Israel Hospital, Harvard Medical School, Boston, Mass.

出版信息

Int Arch Allergy Immunol. 1992;98(2):158-68. doi: 10.1159/000236180.

DOI:10.1159/000236180
PMID:1643441
Abstract

One hundred and seventeen coded intestinal biopsy specimens were examined by electron microscopy. All surgical biopsies were obtained from uninvolved sites of patients with two inflammatory bowel diseases (ulcerative colitis or Crohn's disease) and from patients with preneoplastic and neoplastic diseases (adenocarcinoma, rectal polyp, familial polyposis). Biopsy sites included normal ileum, colon, and rectum as well as conventional ileostomies and continent pouches constructed from the ileum. The data reported here describe the ultrastructural anatomy of human gastrointestinal tract mucosal mast cells in vivo and their anatomic associations with enteric nerves.

摘要

对117份编码的肠道活检标本进行了电子显微镜检查。所有手术活检标本均取自患有两种炎症性肠病(溃疡性结肠炎或克罗恩病)患者的未受累部位,以及患有癌前病变和肿瘤性疾病(腺癌、直肠息肉、家族性息肉病)的患者。活检部位包括正常回肠、结肠和直肠,以及传统回肠造口术和由回肠构建的可控贮袋。本文报道的数据描述了体内人类胃肠道黏膜肥大细胞的超微结构解剖及其与肠神经的解剖学关联。

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Human gut mucosal mast cells: ultrastructural observations and anatomic variation in mast cell-nerve associations in vivo.人类肠道黏膜肥大细胞:超微结构观察及体内肥大细胞与神经关联的解剖学变异
Int Arch Allergy Immunol. 1992;98(2):158-68. doi: 10.1159/000236180.
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Diamine oxidase-gold enzyme-affinity ultrastructural demonstration that human gut mucosal mast cells secrete histamine by piecemeal degranulation in vivo.二胺氧化酶-金酶亲和超微结构证明,人体肠道黏膜肥大细胞在体内通过逐片脱颗粒分泌组胺。
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引用本文的文献

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Cell Mol Gastroenterol Hepatol. 2016 Aug 29;2(6):725-732. doi: 10.1016/j.jcmgh.2016.08.004. eCollection 2016 Nov.
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Quantitative and ultrastructural analysis of rectal mucosal mast cells in acute infectious diarrhea.急性感染性腹泻直肠黏膜肥大细胞的定量及超微结构分析
Dig Dis Sci. 1998 Sep;43(9):2111-6. doi: 10.1023/a:1018875718392.
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Substance P--an underlying factor for pouchitis? Prospective study of substance P- and vasoactive intestinal polypeptide-immunoreactive innervation and mast cells.P物质——袋炎的潜在因素?P物质和血管活性肠肽免疫反应性神经支配及肥大细胞的前瞻性研究。
Dig Dis Sci. 1996 Aug;41(8):1665-71. doi: 10.1007/BF02087922.
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Axonal necrosis of enteric autonomic nerves in continent ileal pouches. Possible implications for pathogenesis of Crohn's disease.可控性回肠储袋中肠自主神经的轴突坏死。对克罗恩病发病机制的可能影响。
Ann Surg. 1993 Mar;217(3):260-71. doi: 10.1097/00000658-199303000-00008.
6
Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade.迟发型超敏反应诱导的小鼠小肠血管通透性增加:感觉神经肽耗竭和NK1受体阻断的抑制作用
Br J Pharmacol. 1995 Apr;114(7):1483-9. doi: 10.1111/j.1476-5381.1995.tb13374.x.