Watanabe Takayuki, Fuse Takahisa, Umezu Masanari, Yamamoto Mitsuharu, Demura Koichiro, Niwa Yuji
Department of Neurosurgery, National Hospital Organization Shizuoka Medical Center, Japan.
Neurol Med Chir (Tokyo). 2006 Jan;46(1):51-4. doi: 10.2176/nmc.46.51.
A 35-year-old man developed osteosarcoma of the left parietal and occipital bones 16 years after radiotherapy for glioma in the right occipital lobe. Radiotherapy of the primary neoplasm used 50 Gy administered to a localized field through two lateral ports. The secondary neoplasm arose contralateral to the primary lesion but within the irradiated field. The tumor had a multilocular cyst with considerable intracranial extension, and symptoms of elevated intracranial pressure were prominent early in the course. After a short-lived initial remission following surgical intervention and chemotherapy, the patient deteriorated because of tumor recurrence and died 18 months after the diagnosis. Radiation-induced osteosarcoma is a well-known but rare complication of radiotherapy for brain neoplasms with a poor prognosis.
一名35岁男性在右侧枕叶胶质瘤放疗16年后发生了左侧顶骨和枕骨骨肉瘤。原发肿瘤放疗时通过两个侧野对局部区域给予50 Gy剂量。继发肿瘤发生在原发病变的对侧，但在照射野内。肿瘤有多个囊肿，颅内扩展明显，病程早期颅内压升高症状突出。手术干预和化疗后有短暂的初始缓解期，但患者因肿瘤复发病情恶化，诊断后18个月死亡。放射性骨肉瘤是脑肿瘤放疗一种已知但罕见的并发症，预后较差。
