人胃酸分泌能力及15-亮氨酸胃泌素-17类似物的消除情况

Acid secretory potency and elimination of the 15-leucine gastrin-17 analogue in man.

作者信息

Petersen B, Christiansen J, Rehfeld J F

机构信息

Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark.

出版信息

Scand J Gastroenterol. 1981 Apr;16(3):437-40. doi: 10.3109/00365528109181994.

DOI:10.3109/00365528109181994

PMID:16435489

Abstract

The effect on gastric acid secretion and the elimination of a commercially available synthetic human gastrin analogue (15-Leucine Synthetic Human Gastrin I, 15-LSG) were studied in six healthy human subjects. On a molar basis acid secretory efficacy was approximately four times greater than pentagastrin and secretory potency ten times greater. Elimination of 15-LSG was bi-exponential, with half-lives of 5.2 +/- 0.8 and 25.9 +/- 7.0 min. Metabolic clearance rate was 6.9 +/- 0.4 ml/kg-min and volume of distribution 52 ml/kg.

摘要

在六名健康人体受试者中研究了一种市售合成人胃泌素类似物（15-亮氨酸合成人胃泌素I，15-LSG）对胃酸分泌的影响及其消除情况。以摩尔为基础，酸分泌效力约为五肽胃泌素的四倍，分泌效能为其十倍。15-LSG的消除呈双指数型，半衰期分别为5.2±0.8分钟和25.9±7.0分钟。代谢清除率为6.9±0.4毫升/千克·分钟，分布容积为52毫升/千克。