海洋天然产物在潜在胰腺癌治疗药物的发现和开发中的作用。
Marine natural products in the discovery and development of potential pancreatic cancer therapeutics.
机构信息
Departments of Drug Discovery, Biomedical Sciences, and Public Health Sciences, Hollings Cancer Center, College of Pharmacy, Medical University of South Carolina, Charleston, SC, United States.
Departments of Drug Discovery, Biomedical Sciences, and Public Health Sciences, Hollings Cancer Center, College of Pharmacy, Medical University of South Carolina, Charleston, SC, United States.
出版信息
Adv Cancer Res. 2019;144:299-314. doi: 10.1016/bs.acr.2019.05.003. Epub 2019 Jun 6.
Pancreatic cancer one of the most deadly cancers and is an increasingly significant concern for global health. The death rates for pancreatic cancer have changed little over time, even with recent expansions of first-line drugs to treat pancreatic cancer there has been little improvement in patient prognosis. Any improvements in treatment strategies will come as a much-needed reprieve to patients diagnosed with this uniquely-challenging disease. Greater attention is needed regarding the identification and development of novel chemotherapeutic strategies with unique mechanisms of action. The marine environment with its particularity has provided a diverse source of novel structural compounds with interesting activities. The marine natural products reported from 2006 to 2018 with compelling activity and potential for the control of pancreatic cancer based on in vitro and in vivo results will be summarized. A key goal of this review is to draw attention to those molecules that warrant additional preclinical development studies.
胰腺癌是最致命的癌症之一，也是全球健康日益关注的问题。尽管近年来一线治疗胰腺癌的药物有所扩展，但胰腺癌的死亡率变化不大，患者的预后几乎没有改善。任何治疗策略的改进都将给被诊断出患有这种极具挑战性疾病的患者带来急需的缓解。需要更加关注识别和开发具有独特作用机制的新型化疗策略。海洋环境具有特殊性，为具有有趣活性的新型结构化合物提供了多样化的来源。本文总结了 2006 年至 2018 年报道的具有体外和体内活性且有潜力控制胰腺癌的海洋天然产物，这些活性和潜力基于体外和体内结果。本文的一个主要目标是引起人们对那些值得进一步进行临床前开发研究的分子的关注。
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