非没食子酰化儿茶素增强儿茶素没食子酸酯介导的金黄色葡萄球菌对苯唑西林的敏感性
Potentiation of catechin gallate-mediated sensitization of Staphylococcus aureus to oxacillin by nongalloylated catechins.
作者信息
Stapleton Paul D, Shah Saroj, Hara Yukihiko, Taylor Peter W
机构信息
Microbiology Group, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):752-5. doi: 10.1128/AAC.50.2.752-755.2006.
Abstract
(-)-Epicatechin gallate (ECg) and (-)-epigallocatechin gallate (EGCg) reduce oxacillin resistance in mecA-containing strains of Staphylococcus aureus. Their binding to staphylococcal cells is enhanced by the nongalloyl analogues (-)-epicatechin (EC) and (-)-epigallocatechin (EGC). EC and EGC significantly increased the capacity of ECg and EGCg to reduce levels of staphylococcal oxacillin resistance.
摘要
（-）-表儿茶素没食子酸酯（ECg）和（-）-表没食子儿茶素没食子酸酯（EGCg）可降低含mecA的金黄色葡萄球菌菌株对苯唑西林的耐药性。非没食子酰类似物（-）-表儿茶素（EC）和（-）-表没食子儿茶素（EGC）可增强它们与葡萄球菌细胞的结合。EC和EGC显著提高了ECg和EGCg降低葡萄球菌对苯唑西林耐药水平的能力。
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