表没食子儿茶素没食子酸酯对青霉素酶的抑制作用导致青霉素对产青霉素酶金黄色葡萄球菌的抗菌活性得以恢复。
Inhibition of penicillinase by epigallocatechin gallate resulting in restoration of antibacterial activity of penicillin against penicillinase-producing Staphylococcus aureus.
作者信息
Zhao Wei-Hua, Hu Zhi-Qing, Hara Yukihiko, Shimamura Tadakatsu
机构信息
Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 2002 Jul;46(7):2266-8. doi: 10.1128/AAC.46.7.2266-2268.2002.
Abstract
The combination of epigallocatechin gallate (EGCg, a main constituent of tea catechins) with penicillin showed synergism against 21 clinical isolates of penicillinase-producing Staphylococcus aureus. Besides binding directly to peptidoglycan, the inhibition of penicillinase activity by EGCg is responsible for the synergism. EGCg inhibited the penicillinase activity in a dose-dependent fashion, with a 50% inhibitory concentration of 10 microg/ml.
摘要
表没食子儿茶素没食子酸酯（EGCg，茶儿茶素的主要成分）与青霉素联合使用时，对21株产青霉素酶金黄色葡萄球菌临床分离株显示出协同作用。除了直接与肽聚糖结合外，EGCg对青霉素酶活性的抑制作用是产生协同作用的原因。EGCg以剂量依赖方式抑制青霉素酶活性，50%抑制浓度为10微克/毫升。
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