Poulet James F A, Hedwig Berthold
Laboratory of Sensory Processing, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Science. 2006 Jan 27;311(5760):518-22. doi: 10.1126/science.1120847.
How do animals discriminate self-generated from external stimuli during behavior and prevent desensitization of their sensory pathways? A fundamental concept in neuroscience states that neural signals, termed corollary discharges or efference copies, are forwarded from motor to sensory areas. Neurons mediating these signals have proved difficult to identify. We show that a single, multisegmental interneuron is responsible for the pre- and postsynaptic inhibition of auditory neurons in singing crickets (Gryllus bimaculatus). Therefore, this neuron represents a corollary discharge interneuron that provides a neuronal basis for the central control of sensory responses.
动物在行为过程中如何区分自身产生的刺激和外部刺激，并防止其感觉通路脱敏？神经科学中的一个基本概念指出，被称为伴随放电或传出副本的神经信号从运动区域转发到感觉区域。介导这些信号的神经元已被证明难以识别。我们发现，单个多节段中间神经元负责对鸣蟋蟀（双斑蟋）听觉神经元的突触前和突触后抑制。因此，该神经元代表一个伴随放电中间神经元，为感觉反应的中枢控制提供了神经基础。
