外差相干反斯托克斯拉曼散射（CARS）成像。

Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging.

作者信息

Potma Eric O, Evans Conor L, Xie X Sunney

机构信息

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

出版信息

Opt Lett. 2006 Jan 15;31(2):241-3. doi: 10.1364/ol.31.000241.

DOI:10.1364/ol.31.000241

PMID:16441043

Abstract

We have achieved rapid nonlinear vibrational imaging free of nonresonant background with heterodyne coherent anti-Stokes Raman scattering (CARS) interferometric microscopy. This technique completely separates the real and imaginary responses of nonlinear susceptibility chi(3) and yields a signal that is linear in the concentration of vibrational modes. We show that heterodyne CARS microscopy permits the detection of weak vibrational resonances that are otherwise overshadowed by the strong interference of the nonresonant background.

摘要

我们通过外差相干反斯托克斯拉曼散射（CARS）干涉显微镜实现了无非共振背景的快速非线性振动成像。该技术完全分离了非线性极化率χ(3)的实部和虚部响应，并产生一个与振动模式浓度呈线性关系的信号。我们表明，外差CARS显微镜能够检测到微弱的振动共振，否则这些共振会被非共振背景的强干扰所掩盖。