Malinovskaya Svetlana A, Malinovsky Vladimir S
Department of Physics and Engineering Physics, Stevens Institute of Technology, Hoboken, New Jersey 07030, USA.
Opt Lett. 2007 Mar 15;32(6):707-9. doi: 10.1364/ol.32.000707.
Two novel control methods based on adiabatic passage are proposed to be implemented in coherent anti-Stokes Raman scattering (CARS) microscopy for noninvasive imaging of biological structure and dynamics. The first method provides optimal pulse-area control of the resonant vibrational transitions by using a pair of equally linear-chirped pulses. The second method, named the 'roof' method, utilizes the chirp sign variation at the central time and gives robust adiabatic excitation of the resonant vibrational mode. Both methods are robust with respect to suppression of the off-resonant transitions. The methods allow one to achieve chemical sensitivity with high resolution and can be used to obtain CARS spectra of biological molecules with efficiently suppressed background.
提出了两种基于绝热通道的新型控制方法，用于在相干反斯托克斯拉曼散射（CARS）显微镜中对生物结构和动力学进行无创成像。第一种方法通过使用一对等线性啁啾脉冲来实现共振振动跃迁的最佳脉冲面积控制。第二种方法称为“屋顶”方法，它利用中心时刻的啁啾符号变化，对共振振动模式进行稳健的绝热激发。两种方法在抑制非共振跃迁方面都很稳健。这些方法能够以高分辨率实现化学灵敏度，可用于获得背景有效抑制的生物分子的CARS光谱。
