Yim Eun-Kyoung, Park Jong-Sup
Department of Obstetrics & Gynecology, Catholic University Medical College, Seoul, 137-040, Republic of Korea.
Expert Rev Proteomics. 2006 Feb;3(1):21-36. doi: 10.1586/14789450.3.1.21.
Cervical cancer is one of the leading causes of cancer morbidity and mortality in women worldwide. More than 98% of cases are related to a human papillomavirus (HPV) infection. Infection with specific subtypes of HPV has been strongly implicated in cervical carcinogenesis. The identification and functional verification of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information for understanding cervical carcinogenesis and the development of cervical cancer-specific markers. In addition, proteomic profiling of altered proteins by anticancer drugs on cervical cancer cells may contribute to providing the fundamental resources for investigation of disease-specific target proteins, elucidation of the novel mechanisms of action and development of new drugs. The advent of proteomics has provided the hope of discovering novel biological markers for use in the screening, early diagnosis and prediction of response to therapy. This review describes the studies where profiles of protein expression in cervical cancer have been generated.
宫颈癌是全球女性癌症发病和死亡的主要原因之一。超过98%的病例与人类乳头瘤病毒（HPV）感染有关。特定HPV亚型的感染与宫颈癌发生密切相关。鉴定与HPV E6和E7癌蛋白相关的宿主蛋白并进行功能验证，可能为理解宫颈癌发生及开发宫颈癌特异性标志物提供有用信息。此外，抗癌药物对宫颈癌细胞中蛋白质变化的蛋白质组学分析，可能有助于为研究疾病特异性靶蛋白、阐明新的作用机制及开发新药提供基础资源。蛋白质组学的出现为发现用于筛查、早期诊断和预测治疗反应的新型生物标志物带来了希望。本综述描述了有关生成宫颈癌蛋白质表达谱的研究。
