College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China.
College of Sciences, Hangzhou Dianzi University, Hangzhou 310018, China.
Database (Oxford). 2022 Mar 26;2022. doi: 10.1093/database/baac018.
Human papillomavirus (HPV) can cause condyloma acuminatum and cervical cancer. Some mutations of these viruses are closely related to the persistent infection of cervical cancer and are ideal cancer vaccine targets. Several databases have been developed to collect HPV sequences, but no HPV mutation database has been published. This paper reports a Chinese HPV mutation database (HPVMD-C), which contains 149 HPV genotypes, 468 HPV mutations, 3409 protein sequences, 4727 domains and 236 epitopes. We analyzed the mutation distribution among HPV genotypes, domains and epitopes. We designed a visualization tool to display these mutations, domains and epitopes and provided more detailed information about the disease, region and related literature. We also proposed an HPV genotype prediction tool, which can predict HPV carcinogenic or non-carcinogenic risk genotypes. We expect that HPVMD-C will complement the existing database and provide valuable resources for HPV vaccine research and cervical cancer treatment. HPVMD-C is freely available at Database URL: http://bioinfo.zstu.edu.cn/hpv.
人乳头瘤病毒（HPV）可引起尖锐湿疣和宫颈癌。这些病毒的一些突变与宫颈癌的持续感染密切相关，是理想的癌症疫苗靶点。已经开发了多个数据库来收集 HPV 序列，但尚未发表 HPV 突变数据库。本文报告了一个中国 HPV 突变数据库（HPVMD-C），其中包含 149 种 HPV 基因型、468 种 HPV 突变、3409 种蛋白质序列、4727 个结构域和 236 个表位。我们分析了 HPV 基因型、结构域和表位之间的突变分布。我们设计了一个可视化工具来显示这些突变、结构域和表位，并提供了有关疾病、区域和相关文献的更详细信息。我们还提出了一种 HPV 基因型预测工具，可预测 HPV 致癌或非致癌风险基因型。我们希望 HPVMD-C 将补充现有的数据库，并为 HPV 疫苗研究和宫颈癌治疗提供有价值的资源。HPVMD-C 可在数据库网址免费获取：http://bioinfo.zstu.edu.cn/hpv。
