HPV E6 和 E7 癌蛋白在 HPV 相关宫颈癌发生中的作用。
The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis.
机构信息
Department of Obstetrics and Gynecology, The Catholic University of Korea College of Medicine, Seoul, Korea.
出版信息
Cancer Res Treat. 2005 Dec;37(6):319-24. doi: 10.4143/crt.2005.37.6.319. Epub 2005 Dec 31.
Abstract
Cervical cancer is one of the leading world causes of cancer morbidity and mortality in woman, with more than 98% related to a human papillomavirus (HPV) infection origin. Infection with specific subtypes of HPV has been strongly implicated in cervical carcinogenesis. The identification and functional verification of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis and the development of cervical cancer-specific markers. The advent of functional genomics and proteomics has provided hope of discovering novel biological markers for use in the screening, early diagnosis, prognostication and prediction of response to therapy. Herein, we review the studies where the profiles of host proteins associated with HPV E6 and E7 oncoproteins in cervical cancer were generated.
摘要
宫颈癌是全球女性癌症发病率和死亡率的主要原因之一，其中超过 98%与 HPV 感染有关。HPV 特定亚型的感染与宫颈癌的发生密切相关。鉴定和功能验证与 HPV E6 和 E7 癌蛋白相关的宿主蛋白可能为了解宫颈癌的发生和开发宫颈癌特异性标志物提供有用的信息。功能基因组学和蛋白质组学的出现为发现用于宫颈癌筛查、早期诊断、预后和预测治疗反应的新型生物标志物带来了希望。在此，我们综述了与 HPV E6 和 E7 癌蛋白相关的宿主蛋白在宫颈癌中的表达谱的研究。
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