Magalhaes Sandra Lira Bastos de, Reforme Olga Maria Rojas, Guzmán Raquel Liriano, Fukuda Yotaka, Barbosa Flávia
Braz J Otorhinolaryngol. 2005 Mar-Apr;71(2):188-91. doi: 10.1016/s1808-8694(15)31309-4. Epub 2005 Aug 2.
Cholesteatoma is a well-known infection resembling a pearl. Its histological aspect is of an epidermal cyst formation characterized by epidermal-keratinized tissue in the middle ear and mastoid that can migrate and erode to adjacent structures.
To verify epidermal cyst (cholesteatoma) growth through implantation of auricular skin of a mouse next to its femoral bone.
Experimental.
Ten healthy rats between two and five months of age and of both sexes underwent implantation of auricular skin on the femoral bone during a three-month period. Paraffin-embedded sections were obtained from the sample and stained with hematoxylin and eosin for pathology investigation.
Macroscopic view: round soft yellowish granulation tissue. Microscopic view: keratinizing stratified squamous epithelium cystic formation. The cyst presented innermost corneal layer, resulted from keratinized skin, followed by granulated and squamous layers, and outermost basal layer.
Growth of epidermal cyst (cholesteatoma) may start from a transplanted epithelial tissue next to the femoral bone of rats.
胆脂瘤是一种众所周知的类似珍珠的感染性病变。其组织学表现为表皮囊肿形成，特征是中耳和乳突内有表皮角化组织，可迁移并侵蚀相邻结构。
通过在小鼠股骨旁植入耳廓皮肤来验证表皮囊肿（胆脂瘤）的生长情况。
实验性研究。
在三个月期间，对10只年龄在2至5个月、雌雄不限的健康大鼠在股骨上植入耳廓皮肤。从样本中获取石蜡包埋切片，并用苏木精和伊红染色进行病理学研究。
宏观观察：圆形柔软淡黄色肉芽组织。微观观察：角化复层鳞状上皮囊肿形成。囊肿呈现最内层角质层，由角化皮肤形成，其次是颗粒层和鳞状层，以及最外层基底层。
表皮囊肿（胆脂瘤）的生长可能始于大鼠股骨旁移植的上皮组织。
