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AUSCAN骨关节炎手部指数的效度、因子结构及临床相关性

Validity, factor structure, and clinical relevance of the AUSCAN Osteoarthritis Hand Index.

作者信息

Allen Kelli D, Jordan Joanne M, Renner Jordan B, Kraus Virginia B

机构信息

Durham Veterans Affairs Medical Center, Durham, North Carolina, USA.

出版信息

Arthritis Rheum. 2006 Feb;54(2):551-6. doi: 10.1002/art.21615.

Abstract

OBJECTIVE

The Australian/Canadian (AUSCAN) Osteoarthritis Hand Index is a self-report assessment of pain, stiffness, and function in patients with hand osteoarthritis (OA). Small studies have confirmed the reliability, construct validity, and responsiveness of this measure, but the factor structure has not been examined. In this study, we examined the clinimetric properties and clinical relevance of the AUSCAN index in a large sample of patients with familial hand OA.

METHODS

The study group comprised 700 patients (80% female, mean age 69 years) who were part of a study on the genetics of generalized OA. All patients had radiographic hand OA bilaterally. The analyses examined internal consistency, factor structure, and relationships of the subscales to grip and pinch strength and a single-item pain measure.

RESULTS

Internal consistency was high for the total AUSCAN index and the subscales (Cronbach's alpha = 0.93-0.96). The AUSCAN function subscale had the strongest correlation with grip and pinch strength, and the pain subscale had the strongest correlation with the single-item pain measure, thus supporting the construct validity of these subscales. Factor analysis showed that all pain and function items clearly loaded on the subscale they were intended to measure. Each 1-unit increase in the AUSCAN function subscale was associated with a clinically relevant decrease in hand strength.

CONCLUSION

The results of this study strongly confirm the clinimetric properties of the AUSCAN index, including the validity of specific subscales. Results indicate that the AUSCAN index can measure meaningful changes in pain, stiffness, and function.

摘要

目的

澳大利亚/加拿大(AUSCAN)手部骨关节炎指数是一种对手部骨关节炎(OA)患者的疼痛、僵硬和功能进行自我报告的评估方法。小型研究已证实该测量方法的可靠性、结构效度和反应性,但尚未对其因子结构进行检验。在本研究中,我们在大量家族性手部OA患者样本中检验了AUSCAN指数的临床测量特性和临床相关性。

方法

研究组由700名患者(80%为女性,平均年龄69岁)组成,他们是一项关于全身性OA遗传学研究的一部分。所有患者双侧手部均有影像学证实的OA。分析考察了内部一致性、因子结构以及各分量表与握力、捏力和单项疼痛测量指标之间的关系。

结果

AUSCAN总指数及其分量表的内部一致性较高(Cronbach's α = 0.93 - 0.96)。AUSCAN功能分量表与握力和捏力的相关性最强,疼痛分量表与单项疼痛测量指标的相关性最强,从而支持了这些分量表的结构效度。因子分析表明,所有疼痛和功能项目均清晰地载荷于其预期测量的分量表上。AUSCAN功能分量表每增加1个单位,手部力量就会出现具有临床意义的下降。

结论

本研究结果有力地证实了AUSCAN指数的临床测量特性,包括特定分量表的效度。结果表明,AUSCAN指数能够测量疼痛、僵硬和功能方面有意义的变化。

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