Mecomber Justin S, Stalcup Apryll M, Hurd Doug, Halsall H Brian, Heineman William R, Seliskar Carl J, Wehmeyer Kenneth R, Limbach Patrick A
Department of Chemistry, University of Cincinnati, Ohio 45221-0072, USA.
Anal Chem. 2006 Feb 1;78(3):936-41. doi: 10.1021/ac051523y.
A study comparing the electrophoretic separation performance attainable from microchips molded by masters fabricated using conventional CNC machining techniques with commercial microchips, wire imprinted microchips, and microchips from LIGA molding devices is presented. An electrophoresis-based detection system using fluorescence microscopy was used to determine the analytical utility of these microchips. The separation performance of CNC microchips was comparable to commercially available microchips as well as those fabricated from LIGA masters. The important feature of the CNC machined masters is that they have rapid design-to-device times using routinely available machining tools. This low-cost prototyping approach provides a new entry point for researchers interested in thermoplastic microchips and can accelerate the development of polymer-based lab-on-a-chip devices.
本文介绍了一项研究，该研究比较了使用传统计算机数控（CNC）加工技术制造的母版模制的微芯片与商用微芯片、线压印微芯片以及LIGA成型设备制造的微芯片的电泳分离性能。使用基于荧光显微镜的电泳检测系统来确定这些微芯片的分析效用。CNC微芯片的分离性能与市售微芯片以及由LIGA母版制造的微芯片相当。CNC加工母版的重要特点是，使用常规可用的加工工具，它们从设计到制成器件的时间很快。这种低成本的原型制作方法为对热塑性微芯片感兴趣的研究人员提供了一个新的切入点，并可以加速基于聚合物的芯片实验室设备的开发。
