Sano Ken-Ichi, Sasaki Hiroyuki, Shiba Kiyotaka
Department of Protein Engineering, Cancer Institute, Japanese Foundation for Cancer Research and CREST, JST, Koto, Tokyo 135-8550, Japan.
J Am Chem Soc. 2006 Feb 8;128(5):1717-22. doi: 10.1021/ja057262r.
Peptide aptamers (=binders) against inorganic materials often show a capacity for mineralization of their target atoms; thus they are able to function both as binding molecules and as mediators for mineralization. Although the mechanisms underlying these two properties of peptide aptamers are not yet fully understood, they have been used separately to fabricate various nanostructures. Here, we present a novel method of nanofabrication, in which binding and mineralization by a peptide aptamer are alternately utilized to assemble multilayered nanostructures comprised of metal loaded cage proteins ornamented with Ti-binding peptides.
