巴西亚马逊地区混合人群中HV-I的核苷酸变异性。
Nucleotide variability of HV-I in admixed population of the Brazilian Amazon Region.
作者信息
Feio-Dos-Santos Ana Cecília, Carvalho Bruno Maia, Batista dos Santos Sidney Emanuel, Ribeiro-dos-Santos Andrea Kely Campos
机构信息
Laboratório de Genética Humana e Médica, Departamento de Patologia, Universidade Federal do Pará, Belém, Pará, Brazil.
出版信息
Forensic Sci Int. 2006 Dec 20;164(2-3):276-7. doi: 10.1016/j.forsciint.2005.12.032. Epub 2006 Jan 31.
The analysis of genetic variation in the nucleotide sequences of mitochondrial DNA has been used as a tool in the study of history of different human populations, as Amerindians, Afro-descendents populations and furthermore admixed populations. In this study, the mitochondrial DNA was analyzed in 158 unrelated individuals in an admixed population of the Amazonian Region: Santarém-PA-Brazil. The polymorphisms were detected using both levels, analysis of restriction enzyme and direct sequencing. We observed a total of 49 different haplotypes were found determined by 46 variable nucleotides. The more frequent haplotypes (Hap03) was shared by five samples and 43 sequences were unique. The genetic diversity was estimated to 0.989+/-0.0067 and the probability of two random individuals showed identical mitochondrial DNA (mtDNA) haplotypes were 2.8%.
线粒体DNA核苷酸序列中的遗传变异分析已被用作研究不同人类群体历史的工具，如美洲印第安人、非洲裔群体以及混合群体。在本研究中，对巴西帕拉州圣塔伦亚马逊地区一个混合群体的158名无亲缘关系个体的线粒体DNA进行了分析。使用限制性酶切分析和直接测序两种水平检测多态性。我们观察到，由46个可变核苷酸确定共发现了49种不同的单倍型。最常见的单倍型（Hap03）由五个样本共享，43个序列是独特的。遗传多样性估计为0.989±0.0067，两个随机个体具有相同线粒体DNA（mtDNA）单倍型的概率为2.8%。
Zotero 插件