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精神分裂症患者在反扫视任务中表现出即时错误相关的表现调整完整。

Schizophrenia patients show intact immediate error-related performance adjustments on an antisaccade task.

作者信息

Polli Frida E, Barton Jason J S, Vangel Mark, Goff Donald C, Iguchi Lisa, Manoach Dara S

机构信息

Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA.

出版信息

Schizophr Res. 2006 Feb 28;82(2-3):191-201. doi: 10.1016/j.schres.2005.10.003. Epub 2006 Jan 30.

Abstract

OBJECTIVE

Schizophrenia patients consistently show impairments on tasks requiring inhibition such as the antisaccade task. Deficits in performance monitoring including the detection of errors and subsequent adjustments to performance may contribute to such impairments. We examined whether immediate error-related performance adjustments during the antisaccade task were intact in schizophrenia.

METHOD

We compared 21 schizophrenia patients and 14 healthy control subjects on the following measures: 1) error-related, trial-by-trial adjustments in reaction time (pre-error speeding, faster errors and post-error slowing); 2) the speed-accuracy trade-off (SATO) function; and 3) the frequency and type of error self-correction.

RESULTS

Although antisaccade performance in schizophrenia was characterized by increased errors and latency of correct responses, measures of immediate error-related performance adjustments were intact.

CONCLUSION

Schizophrenia is characterized by intact immediate error-related performance adjustments, even in the context of impaired antisaccade performance. It is possible that deficiencies in other aspects of error processing, indexed by electrophysiological and hemodynamic markers, contribute to antisaccade and other cognitive deficits in schizophrenia.

摘要

目的

精神分裂症患者在需要抑制的任务(如反扫视任务)中持续表现出障碍。包括错误检测及随后对表现进行调整在内的绩效监测缺陷可能导致此类障碍。我们研究了精神分裂症患者在反扫视任务中与错误相关的即时绩效调整是否完整。

方法

我们比较了21名精神分裂症患者和14名健康对照受试者在以下指标上的表现:1)反应时间与错误相关的逐次试验调整(错误前加速、更快错误和错误后减慢);2)速度-准确性权衡(SATO)函数;3)错误自我纠正的频率和类型。

结果

尽管精神分裂症患者的反扫视表现以错误增加和正确反应潜伏期延长为特征,但与错误相关的即时绩效调整指标是完整的。

结论

精神分裂症的特征是与错误相关的即时绩效调整完整,即使在反扫视表现受损的情况下也是如此。由电生理和血流动力学指标所反映的错误处理其他方面的缺陷,可能导致精神分裂症患者的反扫视及其他认知缺陷。

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