Copersino Marc L, Boyd Susan J, Tashkin Donald P, Huestis Marilyn A, Heishman Stephen J, Dermand John C, Simmons Michael S, Gorelick David A
Clinical Pharmacology & Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health & Human Services, Baltimore, Maryland 21224-6823, USA.
Am J Addict. 2006 Jan-Feb;15(1):8-14. doi: 10.1080/10550490500418997.
This study investigates the clinical significance of a cannabis withdrawal syndrome in 104 adult, non-treatment-seeking, primarily cannabis users who reported at least one serious attempt to stop using cannabis. Retrospective self-report data were obtained on eighteen potential cannabis withdrawal symptoms derived from the literature, including co-occurrence, time course, and any actions taken to relieve the symptom. Study findings provide evidence for the clinical significance of a cannabis withdrawal syndrome, based on the high prevalence and co-occurrence of multiple symptoms that follow a consistent time course and that prompt action by the subjects to obtain relief, including serving as negative reinforcement for cannabis use.
本研究调查了大麻戒断综合征在104名成年、未寻求治疗、主要吸食大麻者中的临床意义，这些人报告至少有一次严重的尝试停止使用大麻。通过回顾性自我报告数据，获取了来自文献的18种潜在大麻戒断症状，包括症状的同时出现、时间进程以及为缓解症状所采取的任何行动。研究结果为大麻戒断综合征的临床意义提供了证据，这基于多种症状的高发生率和同时出现，这些症状遵循一致的时间进程，并促使受试者采取行动以获得缓解，包括作为大麻使用的负性强化因素。
