Hwang Jaeuk, Lyoo In Kyoon, Dager Stephen R, Friedman Seth D, Oh Jung Su, Lee Jun Young, Kim Seog Ju, Dunner David L, Renshaw Perry F
Department of Psychiatry, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea.
Am J Psychiatry. 2006 Feb;163(2):276-85. doi: 10.1176/appi.ajp.163.2.276.
Shape differences in the caudate heads and putamen were compared between drug-naive and drug-treated patients with bipolar disorder and healthy comparison subjects by using spherical harmonic (SPHARM) techniques. On the basis of previous studies, the authors hypothesized that the drug-naive patients would exhibit shape differences of the caudate heads and putamen, especially on the right side, relative to the healthy comparison subjects, and that shape differences, relative to healthy comparison subjects, would differ between drug-naive and drug-treated patients.
Brain magnetic resonance images were acquired from 49 bipolar disorder patients (21 drug-naive and 28 drug-treated patients) and 37 healthy comparison subjects. Volumetric measurements were obtained, and SPHARM descriptions were used to measure between-group radius differences in the surfaces of the caudate heads and putamen.
Although no significant between-group volume differences were found in the striatal structures, significant shape differences in the anterior and ventral surfaces of the striatum were observed. Specifically, shape differences, more prominent for the right side, were found for drug-naive bipolar disorder patients, relative to the healthy comparison subjects, but not for drug-treated bipolar disorder subjects.
The findings suggest that drug-naive bipolar disorder patients have shape differences of the striatum, relative to healthy comparison subjects, and that these differences may be modulated by treatment. The findings more generally demonstrate the sensitivity of the SPHARM analytic technique for detecting subtle anatomical shape differences in small brain regions in the absence of volume differences.
运用球谐函数（SPHARM）技术，比较双相情感障碍初治患者、接受药物治疗的患者以及健康对照者尾状核头部和壳核的形状差异。基于先前的研究，作者推测，相对于健康对照者，双相情感障碍初治患者的尾状核头部和壳核会呈现形状差异，尤其是右侧；并且相对于健康对照者，双相情感障碍初治患者和接受药物治疗的患者之间的形状差异也会有所不同。
采集了49例双相情感障碍患者（21例初治患者和28例接受药物治疗的患者）以及37名健康对照者的脑磁共振图像。进行了体积测量，并使用SPHARM描述来测量尾状核头部和壳核表面的组间半径差异。
虽然在纹状体结构中未发现显著的组间体积差异，但观察到纹状体前表面和腹表面存在显著的形状差异。具体而言，相对于健康对照者，双相情感障碍初治患者在右侧的形状差异更为明显，而接受药物治疗的双相情感障碍患者则未出现这种差异。
研究结果表明，相对于健康对照者，双相情感障碍初治患者的纹状体存在形状差异，且这些差异可能会受到治疗的调节。这些结果更广泛地证明了SPHARM分析技术在检测小脑区细微解剖形状差异（在无体积差异的情况下）的敏感性。
