1型痢疾志贺菌喹诺酮耐药决定区中与gyrA和parC突变相关的氟喹诺酮耐药性
Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1.
作者信息
Talukder Kaisar A, Khajanchi Bijay K, Islam Mohammad A, Islam Zhahirul, Dutta Dilip K, Rahman Mustafizur, Watanabe Haruo, Nair Gopinath B, Sack David A
机构信息
ICDDR, B: Centre for Health and Population Research, GPO Box-128, Dhaka, 1000, Bangladesh.
出版信息
Curr Microbiol. 2006 Feb;52(2):108-11. doi: 10.1007/s00284-005-0140-9. Epub 2006 Jan 31.
We examined the quinolone resistance-determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone-susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser83-->Leu, Asp87-->Asn or Gly) and a single mutation (Ser80-->Ile) were detected in the QRDRs of gyrA and parC, respectively.
我们检测了近期从南亚分离出的1型耐药痢疾志贺菌的gyrA、gyrB和parC的喹诺酮耐药决定区（QRDR），并将数据与1978年、1984年和1994年以前疫情相关的喹诺酮敏感菌株进行了比较。在耐氟喹诺酮菌株中，分别在gyrA和parC的QRDR中检测到双突变（Ser83→Leu，Asp87→Asn或Gly）和单突变（Ser80→Ile）。
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