Bentolila Simone
IGM, University Marne la Vallée, Cité Descartes, Marne la Vallée, Cedex 2, 77454, France.
Proc IEEE Comput Soc Bioinform Conf. 2003;2:114-22.
The first successes in cloning experiments and stem cell "reprogramming" have already demonstrated the primordial role of cellular working-space memory and regulatory mechanisms, which use the knowledge stored in the DNA database in read mode. We present an analogy between living systems and informatics systems by considering: 1) the cell cytoplasm as a memory device accessible as read/write; 2) the mechanisms of regulation as a programming language defined by a grammar, a molecular algebra; 3) biological processes as volatile programs which are executed without being written; 4) DNA as a database in read only mode. We also present applications to two biological algorithms: the immune response and glycogen metabolism.
克隆实验和干细胞“重编程”方面的首批成功案例已经证明了细胞工作空间记忆和调节机制的首要作用，这些机制以读取模式利用存储在DNA数据库中的知识。通过考虑以下几点，我们提出了生命系统和信息系统之间的类比：1）将细胞质视为一种可进行读/写操作的存储设备；2）将调节机制视为一种由语法（一种分子代数）定义的编程语言；3）将生物过程视为无需写入即可执行的易失性程序；4）将DNA视为只读模式的数据库。我们还介绍了其在两种生物算法中的应用：免疫反应和糖原代谢。
