Sehdev Rajesh S, Symmons David A D, Kindl Korana
Emergency Department, The Townsville Hospital, Townsville, Queensland, Australia.
Emerg Med Australas. 2006 Feb;18(1):37-44. doi: 10.1111/j.1742-6723.2006.00802.x.
To examine the evidence regarding the use of ketamine for induction of anaesthesia in patients with head injury in the ED.
A literature review using the key words ketamine, head injury and intracranial pressure.
Advice from early literature guiding against the use of ketamine in head injury has been met with widespread acceptance, as reflected by current practice. That evidence is conflicting and inconclusive in regards to the safety of using ketamine in head injury. A review of the literature to date suggests that ketamine could be a safe and useful addition to our available treatment modalities. The key to this argument rests on specific pharmacological properties of ketamine, and their effects on the cerebral haemodynamics and cellular physiology of brain tissue that has been exposed to traumatic injury.
In the modern acute management of head-injured patients, ketamine might be a suitable agent for induction of anaesthesia, particularly in those patients with potential cardiovascular instability.
探讨急诊科使用氯胺酮对颅脑损伤患者进行麻醉诱导的相关证据。
采用关键词氯胺酮、颅脑损伤和颅内压进行文献综述。
早期文献中关于避免在颅脑损伤中使用氯胺酮的建议已被广泛接受，目前的实践也反映了这一点。关于在颅脑损伤中使用氯胺酮的安全性，该证据相互矛盾且尚无定论。对迄今为止的文献回顾表明，氯胺酮可能是现有治疗方式中一种安全且有用的补充。这一观点的关键在于氯胺酮的特定药理特性，以及它们对遭受创伤性损伤的脑组织的脑血流动力学和细胞生理学的影响。
在现代颅脑损伤患者的急性处理中，氯胺酮可能是一种合适的麻醉诱导药物，特别是对于那些有潜在心血管不稳定的患者。
