Wegscheider B J, El-Shabrawi L, Weger M, Ardjomand N, Hermann J, Aberer E, El-Shabrawi Y
Department of Ophthalmology, Medical University of Graz, Graz, Austria.
Eye (Lond). 2007 Apr;21(4):547-9. doi: 10.1038/sj.eye.6702262. Epub 2006 Feb 3.
TNFalpha inhibitors are more widely used in the treatment of intraocular inflammation, thus ophthalmologists should become aware of possible adverse events, associated with this form of treatment. Herein we report two cases of cutaneous adverse events in uveitis patients treated with infliximab. In one patient, the primary outbreak of pustular psoriasis was observed after her third infusion. A second patient developed impetigo contagiosa induced by Staphylococcus aureus. Thus patients undergoing treatment with infliximab should be monitored carefully since dermal infections and pustular psoriasis, which may be triggered by streptococcal infection, may occur under this regime.
肿瘤坏死因子α抑制剂在眼内炎症治疗中的应用更为广泛，因此眼科医生应了解这种治疗方式可能伴随的不良事件。在此，我们报告两例使用英夫利昔单抗治疗的葡萄膜炎患者发生皮肤不良事件的病例。其中一名患者在第三次输注后出现脓疱型银屑病初发。另一名患者发生了由金黄色葡萄球菌引起的脓疱疮。因此，接受英夫利昔单抗治疗的患者应接受仔细监测，因为在这种治疗方案下可能会发生由链球菌感染引发的皮肤感染和脓疱型银屑病。
