卡介苗免疫对实验感染猴疱疹病毒的狨猴的影响。
Effect of bacillus Calmette-Guérin immunization in marmosets infected experimentally with Herpesvirus saimiri.
作者信息
Schauf V, Falk L, Deinhardt F
出版信息
J Natl Cancer Inst. 1975 Mar;54(3):721-6.
Eight white-lipped marmosets immunized with BCG and 3 sham-immunized marmosets were studied after inoculation with Herpesvirus saimiri (HVS). BCG immunization had no significant influence on the incidence of infection by HVS, incidence of fatal malignant lymphoma, time of leukemia onset, development or titer of HVS antibodies, or average survival time. One BCG-immunized, HVS-infected marmoset failed to develop malignant lymphoma, whereas the remaining 10 HVS-infected marmosets died of malignant lymphoma. Prolonged survival occurred also in 1 marmoset immunized with BCG 100 days after HVS inoculation. The development and disappearance of lymphocyte reactivity to tuberculin were followed in 4 BCG-immunized marmosets.
八只接种卡介苗的白唇狨和三只假免疫的狨在接种猴疱疹病毒（HVS）后接受了研究。卡介苗免疫对HVS感染的发生率、致命性恶性淋巴瘤的发生率、白血病发病时间、HVS抗体的产生、发展或滴度，或平均存活时间均无显著影响。一只接种卡介苗且感染HVS的狨未发生恶性淋巴瘤，而其余10只感染HVS的狨死于恶性淋巴瘤。在接种HVS 100天后接种卡介苗的一只狨也出现了存活期延长的情况。对4只接种卡介苗的狨跟踪观察了其对结核菌素的淋巴细胞反应性的产生和消失情况。
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